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The supply crisis that plagued Ozempic and Mounjaro in 2023-2024 proved that manufacturing capacity is just as important as clinical data

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The authors hypothesize that this paradoxical worsening is due to a cytokine imbalance, similar to what is seen with the exacerbation of disease after administration of biological treatments like anti-TNF, which increases interferon (IFN)- release and leukocyte chemotaxis [25]

of quadruplicate measurements